difference between 2 medications and cite from these sources: 1-pharmacokinetics and pharmacodynamics of tiotropium solition & tiotropium powder in chronic obstructive pulmonary disease( 2014) by hohlfeld. 2- comparison of pharmacokinetics and pharmacodynamics once daily respimat and handihaler in COPD parients( 2013) by sharma. 3- tiotropim respimat versus handihaler of comparsion of bronchodilator efficacy of various doses in clinical trials by 2016 (calverley)
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