oral capsule dose required to reach a mean

By admin / April 27, 2020

Calculate the oral capsule dose required to reach a mean transit time of7 h for a drug if you know the mean absorption time of this drug is3 h, the area under first moment curve is 350 mg*h2/L and the drug volume of distribution is 5 L. Use your knowledge in pharmacokinetics and NCA to proof why the blood will take a full day to become totally free of the drug after administration a single capsule of your calculated dose (hint: consider both half-lives from ka and ke)? Show your calculations.

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